I had multifx gt6 way back when. Never bonded with it. Im a 1 trick pony kinda guy. I like 1 drive, 1 clean and 1 boost. So i always played straight into the amp with a simple channel switcher. Now that i have a single channel amp.. i play into a drive that goes into a clean amp on the verge of breakup.
So depnding on amp. If the amp has reverb. I simply go into a drive and stack pedal. If the amp has no reverb.. i go into the same.. but then have reverb and delay going i to effects loop.
The 11rack i precinfugured a bunch of sounds on 5 or 6 banks. All have a clean. A breakup. A drive. Heavy drive and high gain. That i control with a roland midi controller which basically turns it into a multifx.
But my drive sounds all sound helluva similar.
The 11r i use exclusively into the daw. Although i can bypass all the amp sims and go straight into an amp too.. its just too big a pita to do though.