Personally, I'd rather do pedalboard and real tube amp (either with a cab in a live setting or with a loadbox and IR loader like my Mooer Radar and IR in my 'bedroom' context) but for me, that's mostly cause I don't really use many effects really.
If I was to use a multifx device of some form, it'd be with the Line 6 Helix (or one of the 'mini' versions). It's epic what sounds you can get out of it and it's in a much nicer form factor and more 'usable' than a Kemper for me.
I just find it really easy to hear when a digital high gain sound is used (digital sounding high end - in Youtube blind tests I can always pick out the real amp between a Kemper, Helix etc.) and much prefer a real tube amp.
I do love the look of the Synergy modular amps though - great sounding and interchangeable preamp modules (to my ears, the preamp makes the biggest difference to tone where the power section adds a little extra colour):
For a cheaper option, I would look into the Mooer Preamp pedals, run them into the effects return on my JCM 900 and be able to have different sounding amps on the fly for variety.
My current setup that suits me fine is Guit - Tubescreamer - JCM900 - Mooer Radar with and IR and some EQing - Interface (I have a delay pedal for when I need it, an NS2 noise gate and a Zoom 505ii (lol) for other effects like Chorus when I want to play clean sections)
Other than that, I have high gain bridge pickups that I use 99% of the time and I only ever use neck pickups when I play clean.