ezietsman
Using a guitar amp as a monitor is not wise. The amp and the speaker in the amp is not meant to reproduce an input signal perfectly and they don't in general. They usually have quite severe bass and treble roll-off.
If you are using a modeller into the front of a guitar amplifier, it will likely be better to switch off any cab/speaker simulations you have switched on in the modeller, as these are not needed when you have a real amp/cab/speaker to take care of the treble and bass roll-off.
If you are using the HD400 into something that does reproduce input signals perfectly e.g. recording software, PA, headphones etc then you should have the amp/cab sims on, else it'll sound VERY harsh.
AlanRatcliffe
+1. Save versions of your patches without amp and speaker sims (or if you are using amp drives, at least without speaker sims) for use with your guitar amp.
If you want to use the amp sims, plug the POD into the effects return of the amp and disable the speaker sims. This effectively bypasses your amp's preamp too, just using it as a power amp and guitar speaker cabinet. Obviously your amp must have an effects send/return to do this.
If you want to use your amp's preamp too, search the forum or Google for the "four cable method". You also need an amp send/return for this.