I probably do not understand the question (give us a example of what you are thinking please?)
Annndd there are many here who have a far better grasp on theory than I do...but for what it's worth.
1. A chord is derived from a scale. E.g. C Major chord = 1st, 3rd and 5th notes of the C Major scale. (C, E , G)
If you want to figure out what other chords you could play in a C Major progression, you could "harmonize" the C Major Scale which means C Maj, D min, E min, F Maj, G Maj, A min, B dim could all work in that progression and be in the key of C and retain the Major feel (I think of it as happy/nursery rhyme-y).
Here's a link to a example :
http://www.coniferguitar.com/Scales_for_guitar/page56/page58/Charmonizedscale.html
We did a challenge a while ago using the "axis of awesome" comedy sketch as a basis. Basically four chords typically featured in pop music : here's a reddiit article that explains the theory behind it (far better than I will ever be able to) -
https://www.reddit.com/r/explainlikeimfive/comments/1ekl67/
2. If you are playing blues (minor progression), then a simple 8/12 bar progression (regardless of the key) would use the 1st (or I), 4th (IV) and 5th (V) notes of the scale as the chords of the progression. Hence a 8/12 bar blues often referred to as I-IV-V.
So in the key of C it would be C, F, G chords in the progression.
Also called the money chords (in pop) ?