I would just like to summarize some things I picked up from reading this thread.
1. You computer is plenty powerful so it's not the PC. I can almost guarantee that 100%. I had a Core2Duo 2.4GHz PC as my main studio machine for years. It still grafts and can handle big projects. I did a massive contemporary jazz album with it a few years back at 88.2 so I promise, your i5 is more than sufficient.
2. Your system drive is too big. Even if it's partitioned there's still one head there doing all the work. This will definitely slow down your system and cause problems ESPECIALLY at high sample rates. It's best to have a smaller, faster system drive (like an 80GB SSD or a Raptor drive) and to use your large 1TB HDD as the recording drive. Having a further drive to store your VSTi data/samples can also help speed things up. I personally feel this is most likely the cause of your system slow down.
3. 32-bit is not the issue here. It would be if you had a severely out-dated computer, perhaps. It was said earlier by someone that it is "not supported" and while that is true of pretty much all interfaces, it is not directly related to the interface. 32-bit floating point is the INTERNAL PRECISION (something very different) of the software you are using. No interface supports 32-bit FP so that point is moot. Therefore all the audio passing through your interface will be 24-bit. A 32-bit floating point Cubase Project can support any bit depth within itself. It is merely the internal processing that gets applied at 32-bit. Granted, when recording at 32-bit the incoming 24-bit files get written to 32-bit files, but that shouldn't put that much strain on your computer, especially if you're running an i5 with plenty of RAM. There is nothing but zeros beyond the least significant bit of the incoming 24-bit audio so the files still are, for all intents and purposes, 24-bit.
4. If your interface/DAW supports direct monitoring, then use that in conjunction with a higher buffer setting to relieve strain on the processor. Googling the issue now confirms the Scarlet 2i2 does support direct monitoring. This allows you to monitor the input directly while choosing a higher buffer setting. Note that you can't use plugins with this setting however. You can find the setting (a check box) in Device Setup.
5. Lastly, read this article on the Focusrite Answerbase:
http://www.focusrite.com/answerbase/en/article.php?id=1071
Hope that helps.
Cheers ?