Frodo Baggins wrote
You get good buffers that sound great and cheap buffers that sound terrible. A large pedalboard of only true bypass pedals will have tone loss if you aren't using a switching system. It's a good idea to have mostly true bypass pedals, along with one or two pedals with really good buffers. One buffer near the beginning of the chain to buffer the signal through the pedalboard, and possibly another near the end of the chain to buffer the signal through to the amp, but this one is not always necessary.
^ This. That sums it up nicely.
Time based pedals like delays and reverbs also work better with buffered circuits as it allows for the delay/reverb sound to taper off naturally when the effect is turned off. A true-bypass reverb would cut the reverb sound the moment the pedal is bypassed, which sounds quite odd.